Which medications are used for the management of irritable bowel syndrome (IBS)?

Updated: Dec 11, 2019
  • Author: Jenifer K Lehrer, MD; Chief Editor: BS Anand, MD  more...
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Pharmacologic agents used for the management of symptoms in IBS include the following:

  • Anticholinergics/antispasmodics (eg, dicyclomine, hyoscyamine, trimebutine, peppermint oil) [4]

  • Antidiarrheals (eg, diphenoxylate, loperamide)

  • Tricyclic antidepressants (eg, imipramine, amitriptyline)

  • Prokinetic agents

  • Bulk-forming laxatives

  • Serotonin receptor antagonists (eg, alosetron, tegaserod)

  • Chloride channel activators (eg, lubiprostone)

  • Guanylate cyclase C (GC-C) agonists (eg, linaclotide, plecanatide)

  • Altering bacterial flora and gas formation (eg, rifaximin) [5]

  • Sodium-hydrogen exchange 3 (NHE3) inhibitors (eg, tenapanor) [6]

See Treatment and Medication for more detail.

What is irritable bowel syndrome (IBS)? IBS is a condition that involves recurrent abdominal pain as well as abnormal bowel motility, which can include diarrhea and/or constipation.

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