What is the role of antibiotic therapy in the treatment of peritonitis and abdominal sepsis?

Updated: Jul 23, 2019
  • Author: Brian J Daley, MD, MBA, FACS, FCCP, CNSC; Chief Editor: Praveen K Roy, MD, AGAF  more...
  • Print
Answer

Antibiotic therapy is used to prevent local and hematogenous spread of infection and to reduce late complications. [25] Several different antibiotic regimens are available for the treatment of intra-abdominal infections. [25] Both single-agent broad-spectrum therapy and combination therapies have been used. However, no specific therapy has been found to be superior to another therapy. Infection of the abdominal cavity requires coverage for gram-positive and gram-negative bacteria, as well as for anaerobes. Antipseudomonal coverage is recommended in patients who have had previous treatment with antibiotics or who have had a prolonged hospitalization.

Whenever cultures have been obtained, antibiotic therapy should be appropriately focused on the organisms present. The foundations underlying appropriate antimicrobial therapy comprise timing, spectrum, and dosing. [1]  Appropriate resuscitation following known guidelines for sepsis should be instituted as soon as the diagnosis of sepsis is considered.


Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!