What is the significance of bacterial load in the pathogenesis of peritonitis and abdominal sepsis?

Updated: Jul 23, 2019
  • Author: Brian J Daley, MD, MBA, FACS, FCCP, CNSC; Chief Editor: Praveen K Roy, MD, AGAF  more...
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Answer

Bacterial load and the nature of the pathogen also play important roles. Some studies suggest that the number of bacteria present at the onset of abdominal infections is much higher than originally believed (approximately 2 × 108 colony forming unit [CFU]/mL, much higher than the 5 × 105 CFU/mL inocula routinely used for in vitro susceptibility testing). This bacterial load may overwhelm the local host defense.


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