Which medications in the drug class Tetracyclines are used in the treatment of Peritonitis and Abdominal Sepsis?

Updated: Jul 23, 2019
  • Author: Brian J Daley, MD, MBA, FACS, FCCP, CNSC; Chief Editor: Praveen K Roy, MD, AGAF  more...
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Eravacycline is a synthetic fluorocycline antibiotic belonging the tetracycline drug class. Approval for complicated intra-abdominal infections was based on results from the IGNITE-1 clinical trial (n=541) which demonstrated eravacycline to be noninferior to ertapenem. [35]

Eravacycline (Xerava)

Fluorocycline antibacterial within the tetracycline class; disrupts bacterial protein synthesis by binding the 30S ribosomal subunit, thus preventing incorporation of amino acid residues into elongating peptide chains. It is indicated for treatment of complicated intra-abdominal infections caused by the following susceptible bacteria: Escherichia coli, Klebsiella pneumoniae, Citrobacter freundii, Enterobacter cloacae, Klebsiella oxytoca, Enterococcus faecalis, Enterococcus faecium, Staphylococcus aureus, Streptococcus anginosus group, Clostridium perfringens, Bacteroides species, or Parabacteroides distasonis.

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