Which medications in the drug class Tetracyclines are used in the treatment of Peritonitis and Abdominal Sepsis?

Updated: Jul 23, 2019
  • Author: Brian J Daley, MD, MBA, FACS, FCCP, CNSC; Chief Editor: Praveen K Roy, MD, AGAF  more...
  • Print
Answer

Tetracyclines

Eravacycline is a synthetic fluorocycline antibiotic belonging the tetracycline drug class. Approval for complicated intra-abdominal infections was based on results from the IGNITE-1 clinical trial (n=541) which demonstrated eravacycline to be noninferior to ertapenem. [35]

Eravacycline (Xerava)

Fluorocycline antibacterial within the tetracycline class; disrupts bacterial protein synthesis by binding the 30S ribosomal subunit, thus preventing incorporation of amino acid residues into elongating peptide chains. It is indicated for treatment of complicated intra-abdominal infections caused by the following susceptible bacteria: Escherichia coli, Klebsiella pneumoniae, Citrobacter freundii, Enterobacter cloacae, Klebsiella oxytoca, Enterococcus faecalis, Enterococcus faecium, Staphylococcus aureus, Streptococcus anginosus group, Clostridium perfringens, Bacteroides species, or Parabacteroides distasonis.


Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!