Which medications in the drug class Secretagogues are used in the treatment of Intestinal Motility Disorders?

Updated: Sep 16, 2020
  • Author: Mia L Manabat, DO; Chief Editor: Burt Cagir, MD, FACS  more...
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Answer

Secretagogues

Lubiprostone (Amitiza)

Lubiprostone activates chloride channel-2 (ClC-2) chloride channels, increasing intestinal fluid secretion and motility, reducing intestinal permeabiliaty, and stimulating recovery of mucosal barrier function.

Linaclotide (Linzess)

Linaclotide activates guanylate cyclase-C, stimulating cGMP production and increasing intestinal fluid secretion and motility.


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