Which medications in the drug class Proton Pump Inhibitors are used in the treatment of Inflammatory Bowel Disease?

Updated: Oct 17, 2017
  • Author: William A Rowe, MD; Chief Editor: BS Anand, MD  more...
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Answer

Proton Pump Inhibitors

Proton pump inhibitors (PPIs) reduce gastric acid secretion by inhibition of the H+ -K+ -ATPase enzyme system in the gastric parietal cells. These agents are used in patients with severe esophagitis and in patients whose disease is not responsive to H2-antagonist therapy.

Omeprazole (Prilosec)

Omeprazole decreases gastric acid secretion by inhibiting the parietal cell H+/K+-ATPase pump.

Lansoprazole (Prevacid)

Lansoprazole suppresses gastric acid secretion by specific inhibition of the H+/K+-ATPase enzyme system (ie, proton pump) at the secretory surface of the gastric parietal cell. It blocks the final step of acid production. The effect is dose-related and inhibits both basal and stimulated gastric acid secretion, thus increasing the gastric pH.

Esomeprazole magnesium (Nexium)

Esomeprazole magnesium is an S-isomer of omeprazole. It inhibits gastric acid secretion by inhibiting the H+/K+-ATPase enzyme system at the secretory surface of gastric parietal cells. Esomeprazole is used in severe cases and in patients not responding to H2-antagonist therapy. This agent is used for up to 4 weeks to treat and relieve symptoms of active duodenal ulcers; however, it may be used for up to 8 weeks to treat all grades of erosive esophagitis.

Rabeprazole sodium (Aciphex)

Rabeprazole sodium decreases gastric acid secretion by inhibiting the parietal cell H+/K+-ATPase pump.

Pantoprazole (Protonix)

Pantoprazole suppresses gastric acid secretion by specifically inhibiting the H+/K+-ATPase enzyme system at the secretory surface of gastric parietal cells.


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