Which medications in the drug class Antidiarrheals are used in the treatment of Inflammatory Bowel Disease?

Updated: Oct 17, 2017
  • Author: William A Rowe, MD; Chief Editor: BS Anand, MD  more...
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Answer

Antidiarrheals

These agents provide symptomatic relief when patients report symptoms of diarrhea.

Diphenoxylate and atropine (Lomotil)

Diphenoxylate and atropine is a drug combination that acts as an antidiarrheal agent chemically related to the narcotic analgesic meperidine. This agent acts on intestinal muscles to inhibit peristalsis and slow intestinal motility, prolonging the movement of electrolytes and fluid through the bowel, and increasing the viscosity. A subtherapeutic dose of anticholinergic atropine sulfate is added to discourage overdosage, in which case diphenoxylate may clinically mimic the effects of codeine.

Loperamide (Imodium A-D, Diamode)

Loperamide acts on intestinal muscles to inhibit peristalsis and slow intestinal motility. It prolongs the movement of electrolytes and fluid through the bowel and increases viscosity.

Cholestyramine (Questran, Prevalite)

Cholestyramine may be used to treat diarrhea associated with excess bile acids. It binds bile acids, thus reducing the damage to the intestinal mucosa. Cholestyramine also reduces the induction of colonic fluid secretion and forms a nonabsorbable complex with bile acids in the intestine, which, in turn, inhibits enterohepatic reuptake of intestinal bile salts.


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