What is the role of intramuscular MTX in the treatment of inflammatory bowel disease (IBD)?

Updated: Apr 10, 2020
  • Author: William A Rowe, MD; Chief Editor: BS Anand, MD  more...
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Answer

Data on MTX support the use of intramuscular MTX in Crohn disease, but such data are lacking in ulcerative colitis. Methotrexate has been shown to be ineffective to treat ulcerative colitis. [94] Two clinical trials showed that AZA continuation in patients with ulcerative colitis prevented relapse, as compared to those who discontinued the medication. However, other trials have shown trends but no statistically significant benefit of AZA in ulcerative colitis. [95]


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