What is the significance of a greater number of positive anti-Saccharomyces cerevisiae antibodies (ASCA) in the evaluation of inflammatory bowel disease (IBD)?

Updated: Apr 10, 2020
  • Author: William A Rowe, MD; Chief Editor: BS Anand, MD  more...
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Patients with Crohn disease who have a greater number of positive ASCA may be at a greater risk for complications such as strictures and fistulas, and they may also be at a higher risk for surgery. However, serologic markers do not appear to predict response to medical therapy, and there is currently insufficient evidence to recommend the use of antibody testing to predict responses to medical treatment or surgery in patients with IBD. [61]

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