What is the diagnostic significance of positive perinuclear antineutrophil cytoplasmic antibodies (pANCA) results in the evaluation of inflammatory bowel disease (IBD)?

Updated: Apr 10, 2020
  • Author: William A Rowe, MD; Chief Editor: BS Anand, MD  more...
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Note that a variant of Crohn disease particularly involving the colon may result in a positive pANCA test, which may complicate the diagnosis. Serum response to anti-CBir1, an antibody associated with the presence of IBD, has been shown to differentiate pANCA-positive results in ulcerative colitis versus ulcerative colitis–like Crohn disease. [61]

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