What is the quality of life in patients with Crohn disease (CD) compared to those with ulcerative colitis?

Updated: Apr 10, 2020
  • Author: William A Rowe, MD; Chief Editor: BS Anand, MD  more...
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Overall, the patient's quality of life with Crohn disease is generally lower than that of individuals with ulcerative colitis. Data suggest that in persons with Crohn colitis involving the entire colon, the risk of developing malignancy is equal to that in persons with ulcerative colitis; however, the risk is much smaller (albeit poorly quantified) in most patients with Crohn disease primarily involving the small bowel. Intestinal cancer may become a more important long-term complication in patients with Crohn disease because of longer survival.

Studies support evidence that specific CARD15 mutations are associated with the intestinal location of the disease, as well as course and prognosis, [8] and are correlated with the propensity for developing ileal strictures and with an early onset of disease.

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