What is the role of single nucleotide polymorphisms in the etiology of inflammatory bowel disease (IBD)?

Updated: Oct 17, 2017
  • Author: William A Rowe, MD; Chief Editor: BS Anand, MD  more...
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Answer

Single nucleotide polymorphisms in other autophagy genes have also shown association with susceptibility to Crohn disease, such as 2 polymorphisms that flanked the IRGM gene and may exert regulatory control for the gene. [22] Subsequently, there have been a number of other loci implicated in the autophagy pathway that have been associated with Crohn disease. [7]


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