Which medications in the drug class Monoclonal Antibodies are used in the treatment of Inflammatory Bowel Disease?

Updated: Apr 10, 2020
  • Author: William A Rowe, MD; Chief Editor: BS Anand, MD  more...
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Answer

Monoclonal Antibodies

Ustekinumab (Stelara)

Ustekinumab (Stelara) is an antibody that blocks IL-12 and IL-23. It interferes with the triggering of the body's inflammatory response through the suppression of cytokines (interleukins IL-12 and IL-23) which help activate certain T-cells. Ustekinumab binds to the p-40 subunit of both IL-12 and IL-23 so that they subsequently cannot bind to their receptors.


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