Which medications in the drug class DMARDs, JAK Inhibitors are used in the treatment of Inflammatory Bowel Disease?

Updated: Apr 10, 2020
  • Author: William A Rowe, MD; Chief Editor: BS Anand, MD  more...
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Answer

DMARDs, JAK Inhibitors

Tofacitinib (Xeljanz, Xeljanz XR)

Tofacitinib is an inhibitor of the enzyme janus kinase 1 (JAK1) and janus kinase 3 (JAK 3). It interferes with the JAK-STAT signaling pathway, which transmits extracellular information into the cell nucleus, influencing DNA transcription.


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