Which medications in the drug class Bile Acid Sequestrants are used in the treatment of Inflammatory Bowel Disease?

Updated: Apr 10, 2020
  • Author: William A Rowe, MD; Chief Editor: BS Anand, MD  more...
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Answer

Bile Acid Sequestrants

Cholestyramine (Questran, Prevalite)

Cholestyramine may be used to treat diarrhea associated with excess bile acids. It binds bile acids, thus reducing the damage to the intestinal mucosa. Cholestyramine also reduces the induction of colonic fluid secretion and forms a nonabsorbable complex with bile acids in the intestine, which, in turn, inhibits enterohepatic reuptake of intestinal bile salts.

Colestipol (Colestid)

Colestipol forms a soluble complex after binding to bile acid, increasing fecal loss of bile acid-bound low-density lipoprotein cholesterol.

Colesevelam (WelChol)

Colesevelam forms complex with bile acids that is not absorbed through intestine; inhibits enterohepatic reuptake of intestinal bile salts. It can be used for symptomatic chronic diarrhea due to bile salt malabsorption (bile acid diarrhea) secondary to Crohn's disease.


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