What is the potential role of transcription factor 7–like 2 (TCF7L2) in the prevention of type 2 diabetes mellitus?

Updated: Dec 14, 2018
  • Author: Ali Torkamani, PhD; Chief Editor: Keith K Vaux, MD  more...
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Ultimately, TCF7L2 could prove a promising biomarker for disease prevention for those with an elevated genetic predisposition to type 2 diabetes. In the meantime, however, there is no clinical role for routine screening for TCF7L2, and the presence of TCF7L2 variants that are associated with increased risk of type 2 diabetes should be considered in combination with other known predictors when assessing a patient's individual risk for type 2 diabetes.

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