What is the predictive value of transcription factor 7–like 2 (TCF7L2) for type 2 diabetes mellitus?

Updated: Dec 14, 2018
  • Author: Ali Torkamani, PhD; Chief Editor: Keith K Vaux, MD  more...
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Although genetic tests for TCF7L2 could help predict the incidence and the rate of onset of type 2 diabetes, [24] the strongest predictors continue to be positive family history, increased body mass index, increased blood pressure, and increased serum levels of triglycerides, apolipoprotein A-1, and liver enzymes, all of which precede inception of metabolic syndrome. [25] In fact, the predictive power of TCF7L2 variants disappears with lifestyle modifications or metformin treatment, while the improved insulin sensitivity resulting from these changes directly oppose the pathologic influence of TCF7L2 variants. [26] These data suggest that genetic susceptibility to type 2 diabetes as determined by TCF7L2 variants might prove an actionable indicator for early intervention and disease prevention. [23]

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