Which medications in the drug class Gallstone-Solubilizing Agents are used in the treatment of Unconjugated Hyperbilirubinemia?

Updated: Sep 29, 2020
  • Author: Hisham Nazer, MBBCh, FRCP, DTM&H; Chief Editor: BS Anand, MD  more...
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Gallstone-Solubilizing Agents

Ursodeoxycholic acid (or ursodiol) partially replaces the circulating pool of endogenous bile acids. Because it is highly hydrophilic, it replaces toxic detergent bile acids (eg, chenodeoxycholic acid, lithocholic acid). This effect may enhance the biliary excretion of the toxic bile acids and may protect cells against liver-cell toxicity induced by detergent bile acids.

Ursodeoxycholic acid (Actigall, Urso)

This agent decreases liver enzymes (by decreasing liver-cell toxicity) and is therefore recommended in chronic liver disease. Routine administration in Crigler-Najjar syndrome has not been universally adopted.

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