What is the efficacy of hepatocyte transplantation for the treatment of unconjugated hyperbilirubinemia?

Updated: May 21, 2019
  • Author: Hisham Nazer, MBBCh, FRCP, DTM&H; Chief Editor: BS Anand, MD  more...
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Hepatocyte transplantation has become an effective therapy for patients with inborn metabolic errors. It involves catheterization of the portal vein and an infusion of donor hepatocytes. [76, 78, 79, 80]

The immunosuppression regimen is similar to that administered to patients receiving whole-organ transplantation and currently includes tacrolimus and prednisolone.

Stem cells and stem cell–derived hepatocytes should offer the potential to overcome the current limitations on the supply of hepatocytes and on the extent of repopulation of the liver after transplantation. [81]

Hepatocyte transplantation has been reported to decrease the need for phototherapy and to increase the activity of UGT to 5.5% of normal.

In a report, hepatocyte transplantation resulted in bilirubin levels decreasing to and maintaining the long-term stabilization at about 50% of the values found prior to cell infusion. [82]

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