When is liver transplantation indicated in the treatment of unconjugated hyperbilirubinemia?

Updated: Sep 29, 2020
  • Author: Hisham Nazer, MBBCh, FRCP, DTM&H; Chief Editor: BS Anand, MD  more...
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Liver transplantation remains the sole definitive treatment for Crigler-Najjar syndrome type 1. [76, 77] Cadaveric orthotopic and auxiliary and living related liver transplantation have resulted in excellent survival rates and prognoses.

Early liver transplantation in patients with Crigler-Najjar syndrome type 1 decreases the incidence of neurologic deficits, especially for patients in whom reliable administration of phototherapy cannot be guaranteed. [78, 79]

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