What is the role of thin-layer chromatography in the workup of Gilbert syndrome?

Updated: May 21, 2019
  • Author: Hisham Nazer, MBBCh, FRCP, DTM&H; Chief Editor: BS Anand, MD  more...
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Answer

Thin-layer chromatography is diagnostic of Gilbert syndrome when it shows a significantly higher proportion of unconjugated bilirubin than is seen in individuals with chronic hemolysis or liver disease or is found in healthy individuals. If confirmation of the diagnosis is truly essential, chromatographic determination is of potential use. In Gilbert syndrome, this shows an increased ratio of bilirubin monoglucuronide to diglucuronide, reflecting reduced bilirubin-UGT activity.


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