What is the role of a radiolabeled chromium test in the workup of Gilbert syndrome?

Updated: May 21, 2019
  • Author: Hisham Nazer, MBBCh, FRCP, DTM&H; Chief Editor: BS Anand, MD  more...
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Answer

The radiolabeled chromium test is used to measure red blood cell survival. As many as 60% of patients with Gilbert syndrome have a mild and fully compensated state of hemolysis together with increased hepatic heme production. This means that hyperbilirubinemia may develop due to reduced clearance, as well as increased production, of bilirubin, with higher production resulting from increased erythroid or hepatic heme turnover.


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