What is the role of a phenobarbital test in the workup of Gilbert syndrome?

Updated: May 21, 2019
  • Author: Hisham Nazer, MBBCh, FRCP, DTM&H; Chief Editor: BS Anand, MD  more...
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Answer

Phenobarbital and other enzyme inducers of the bilirubin-UGT system will normalize plasma bilirubin levels in patients with Gilbert syndrome. This effect is predominantly due to the accelerated bilirubin clearance from enzyme induction, but it is also due to reduced bilirubin turnover. Steroids can also reduce plasma bilirubin levels in Gilbert syndrome, by increasing the hepatic uptake and storage of bilirubin.


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