Which conditions should be considered in the differential diagnoses of unconjugated hyperbilirubinemia?

Updated: May 21, 2019
  • Author: Hisham Nazer, MBBCh, FRCP, DTM&H; Chief Editor: BS Anand, MD  more...
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Other conditions to be considered include the following:

  • Physiologic neonatal jaundice

  • Hemolysis

  • Hematoma

  • Acute and chronic liver disease

  • Primary hyperbilirubinemia from ineffective erythropoiesis

  • Infections

  • Cardiac disease - Eg, congestive heart failure or prosthetic heart valves

  • Rhabdomyolysis

  • High-altitude living

  • Medications - Eg, probenecid, rifampicin, or other antibiotics

  • Thyrotoxicosis

Additional considerations in the diagnosis of impaired bilirubin conjugation include the following:

  • Dyserythropoiesis

  • Portosystemic shunts

  • Neonates

  • Hyperthyroidism

  • Ethinyl estradiol

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