What is the prognosis of Crigler-Najjar syndrome type 2?

Updated: May 21, 2019
  • Author: Hisham Nazer, MBBCh, FRCP, DTM&H; Chief Editor: BS Anand, MD  more...
  • Print

Although the type 2 form of this disease runs a more benign clinical course than type 1, several cases of bilirubin-induced brain damage have been reported. (Bilirubin encephalopathy occurs usually when patients experience a superimposed infection or stress.) With proper treatment, however, neurologic sequelae can be avoided.

In neonates of mothers with Crigler-Najjar syndrome type 2, the use of phenobarbital in pregnancy appears to be safe, with good fetal and maternal outcome. [49]

Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!