At what age do the symptoms of unconjugated hyperbilirubinemia first appear?

Updated: May 21, 2019
  • Author: Hisham Nazer, MBBCh, FRCP, DTM&H; Chief Editor: BS Anand, MD  more...
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The age at which symptoms of unconjugated hyperbilirubinemia appear varies as follows:

  • Crigler-Najjar syndrome type 1 - Symptoms appear within the first few days of life [48]

  • Crigler-Najjar syndrome type 2 - Symptoms may present later than they do in type 1; patients have jaundice during the first few years of life.

  • Gilbert syndrome – This is usually diagnosed around puberty, possibly because of the inhibition of bilirubin glucuronidation by endogenous steroid hormones

  • Physiologic jaundice affects nearly all newborns, occurs in the first 2-5 days following birth, and resolves within the first several weeks after birth.

  • Breast milk jaundice typically begins after the first 3-5 days, peaks within 2 weeks after birth, and progressively declines to normal levels over 3-12 weeks.

  • Ineffective erythropoiesis (ELB production) - This condition usually emerges at age 20-30 years

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