How does the incidence of unconjugated hyperbilirubinemia vary by sex?

Updated: May 21, 2019
  • Author: Hisham Nazer, MBBCh, FRCP, DTM&H; Chief Editor: BS Anand, MD  more...
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Answer

Gilbert syndrome is diagnosed more commonly in boys after puberty than in girls. The apparent sex difference is due to the fact that the daily bilirubin production is lower in women than in men. The male-to-female ratio for Gilbert syndrome ranges from 2:1 to 7:1.

Crigler-Najjar syndrome occurs in both sexes equally, while neonatal physiologic jaundice occurs more frequently in males.


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