What is the global incidence of unconjugated hyperbilirubinemia?

Updated: May 21, 2019
  • Author: Hisham Nazer, MBBCh, FRCP, DTM&H; Chief Editor: BS Anand, MD  more...
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Crigler-Najjar syndrome is a rare disease. The estimated incidence is 1 case per 1,000,000 births, with only several hundred people worldwide having been reported to have this disease. The syndrome is mostly encountered in communities where high rates of consanguineous marriages prevail.

The prevalence of Gilbert syndrome varies considerably around the world, depending on which diagnostic criteria are used (eg, number of bilirubin determinations, method of analysis, bilirubin levels used for diagnosis, whether the patient was fasting). Estimates of prevalence may be complicated further by molecular genetic studies of polymorphisms in the TATAA promoter region, which affect as many as 36% of Africans but only 3% of Asians.

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