What causes impaired bilirubin conjugation in unconjugated hyperbilirubinemia?

Updated: May 21, 2019
  • Author: Hisham Nazer, MBBCh, FRCP, DTM&H; Chief Editor: BS Anand, MD  more...
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Impaired bilirubin conjugation can result from the following:

  • Crigler-Najjar syndrome types I and II

  • Gilbert syndrome (decreased uptake and/or conjugation)

  • Neonatal physiologic jaundice

  • Breast milk jaundice

  • Maternal serum jaundice

  • Hypothyroidism/hyperthyroidism

  • Ethinyl estradiol

  • Liver diseases - Chronic hepatitis, [19] cirrhosis, and Wilson disease

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