What are the inherited defects of bilirubin conjugation in unconjugated hyperbilirubinemia?

Updated: May 21, 2019
  • Author: Hisham Nazer, MBBCh, FRCP, DTM&H; Chief Editor: BS Anand, MD  more...
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Impaired conjugation of bilirubin

The following inherited defects of bilirubin conjugation are known to exist in humans:

  • Crigler-Najjar syndrome types 1 and 2

  • Gilbert syndrome

Gilbert syndrome is believed to affect approximately 3%-10% of the adult population. [6] Crigler-Najjar syndrome is a much rarer disorder, with only a few hundred cases described in the literature. (See Epidemiology.)

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