What causes ABO/Rh incompatibility leading to neonatal jaundice?

Updated: May 21, 2019
  • Author: Hisham Nazer, MBBCh, FRCP, DTM&H; Chief Editor: BS Anand, MD  more...
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ABO/Rh incompatibility

Neonatal jaundice can also result from an increased bilirubin load or from ABO/Rh incompatibility. With regard to the latter, incompatibility can have the following causes:

  • Inherited red blood cell disorders - Sickle cell disease and hereditary spherocytosis/elliptocytosis

  • Drug reactions

  • Ineffective erythropoiesis - Thalassemia, vitamin B-12 deficiency, and congenital dyserythropoietic anemia

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