What causes impaired hepatic bilirubin uptake in unconjugated hyperbilirubinemia?

Updated: May 21, 2019
  • Author: Hisham Nazer, MBBCh, FRCP, DTM&H; Chief Editor: BS Anand, MD  more...
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Answer

The hepatic uptake of bilirubin can be reduced by the following:

  • Congestive heart failure

  • Surgical/naturally occurring shunts

  • Drugs/contrast agents

Unconjugated hyperbilirubinemia due to drugs/contrast agents resolves within 48 hours of discontinuing the drug; agents that can cause the condition include rifampicin, rifamycin, probenecid, flavaspidic acid, and bunamiodyl (cholecystographic agent).


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