How is Gilbert syndrome diagnosed?

Updated: May 21, 2019
  • Author: Hisham Nazer, MBBCh, FRCP, DTM&H; Chief Editor: BS Anand, MD  more...
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Answer

As a rule, Gilbert syndrome can be diagnosed by a thorough history and physical examination and confirmed by standard blood tests. Laboratory results include the following:

  • Unconjugated hyperbilirubinemia noted on several occasions

  • Normal results of complete blood count (CBC), reticulocyte count, and blood smear

  • Normal liver function test (LFT) results

  • An absence of other disease processes

Specialized tests that have occasionally been used to confirm a diagnosis of Gilbert syndrome include the following:

  • Fasting test

  • Nicotinic acid test

  • Phenobarbital test

  • Radiolabeled chromium test

  • Thin-layer chromatography

  • Drug clearance test

  • Polymerase chain reaction (PCR) assay

  • Percutaneous liver biopsy - Very rarely performed


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