What are the most common etiologies of conjugated hyperbilirubinemia?

Updated: Jul 31, 2019
  • Author: Richard A Weisiger, MD, PhD; Chief Editor: BS Anand, MD  more...
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In a review of the literature, in which Gottesman et al selected 17 studies comprising 1692 infants as meeting their selection criteria for the evaluation of the etiologies of conjugated hyperbilirubinemia, idiopathic neonatal hepatitis was the most common cause in infancy (26.0%), and extrahepatic biliary atresia (25.89%) and infection (11.4%) were the most commonly specified etiologies. [5] Selection criteria were noted as the following [5] :

  • Prospective/retrospective case series or cohort study with at least 10 patients
  • Consecutive infants who presented with conjugated hyperbilirubinemia
  • Patients who received appropriate diagnostic work-up for conjugated hyperbilirubinemia
  • No specific diagnoses were excluded in the studied cohort

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