Which medications in the drug class Anthelmintics are used in the treatment of Hydatid Cysts?

Updated: May 07, 2019
  • Author: Imad S Dandan, MD; Chief Editor: BS Anand, MD  more...
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Answer

Anthelmintics

Treatment of Echinococcus infestation as a primary modality or adjunct to surgery.

Albendazole (Albenza)

Decreases ATP production in the worm, causing energy depletion, immobilization, and, finally, death. Orally administered broad-spectrum anthelmintic with poor aqueous solubility. Poorly absorbed from the GI tract but metabolized quickly to albendazole sulfoxide, which is easily absorbed. Systemic activity is attributed to the first metabolite. Plasma level is noted to rise significantly (as much as 5-fold) when ingested after a high-fat meal. Experience in patients age < 6 y is limited.

Mebendazole (Vermox)

Causes worm death by selectively and irreversibly blocking the uptake of glucose and other nutrients in susceptible adult intestine where helminths dwell. Broad-spectrum synthetic anthelmintic. Metabolites are devoid of anthelmintic activity.


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