What is the role of chemotherapy in the treatment of alveolar echinococcosis (AE)?

Updated: May 07, 2019
  • Author: Imad S Dandan, MD; Chief Editor: BS Anand, MD  more...
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Answer

Note the following:

  • Indications: Chemotherapy with benzimidazoles is used perioperatively for approximately 2 years in patients in whom radical resection is feasible because of possible undetected residual parasite tissue. In patients who undergo a partial resection, patients who are inoperable, or patients who have had a liver transplant, long-term chemotherapy is required (3-10 y).

  • Contraindications: Because chemotherapy is the only treatment in certain cases, contraindications are limited to early pregnancy and severe leukopenia. Chemotherapeutic agents and patient monitoring are the same as with CE, but the length of treatment is different.

  • Outcome: A significant increase in 10-year survival rates exists in patients receiving chemotherapy compared to patients who are not treated (85%-90% vs 10%, respectively).


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