Which genetic mutations elevate small dense low-density lipoprotein cholesterol (sdLDLc) levels?

Updated: Apr 09, 2021
  • Author: Nainesh K Gandhi, MD, MSE; Chief Editor: Keith K Vaux, MD  more...
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LDL particle size has also been associated with increased CHD risk. Increased levels or percentage of small dense low-density lipoprotein cholesterol (sdLDLc) has been correlated with increased future CHD events in the ARIC study. [32] It is thought that increased sdLDLc leads to increased atherogenicity because of a higher LDL particle number or because of more available smaller LDL circulating particles. Elevated sdLDLc has been correlated with increased markers of inflammation, metabolic syndrome, and development of adverse lipid profiles. Many single nucleotide polymorphisms (SNPs) on multiple chromosomal loci and genetic variants in the PCSK7 gene have been implicated in abnormal levels of sdLDLc. [32]


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