Which medications in the drug class Vasopressin analogues are used in the treatment of Hepatorenal Syndrome?

Updated: Oct 16, 2017
  • Author: Deepika Devuni, MD; Chief Editor: BS Anand, MD  more...
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Answer

Vasopressin analogues

Improve circulatory dysfunction secondary to splanchnic vasodilatation. Also improve RPF, the GFR, and urine output.

Ornipressin (POR-8)

Not available in the United States. Synthetic vasopressin analogue with a short half-life that requires continuous IV administration. V1 vasopressin receptors are abundantly expressed in the mesenteric arteries as compared with other vascular areas. Has been used in conjunction with albumin to treat HRS but is associated with ischemic complications.

Terlipressin

Not available in United States. Nonselective V1 vasopressin agonist that has similar vasoconstrictor potency to ornipressin but a lower incidence of ischemic complications. Inactive by itself but is transformed into a biologically active form (lysine-vasopressin) by the action of tissue endopeptidases and exopeptidases. Due to its longer half-life (2-10 h) compared to ornipressin, terlipressin may be administered as a bolus. It has lower incidence of adverse ischemic effects, with < 5% of cases reported in a series of 1258 patients receiving it for variceal bleeding.


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