What are the treatment guidelines for hepatitis C genotype 2 or 3 with decompensated cirrhosis following liver transplantation?

Updated: Oct 07, 2019
  • Author: Vinod K Dhawan, MD, FACP, FRCPC, FIDSA; Chief Editor: BS Anand, MD  more...
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Answer

◊ HCV genotype 2 or 3 allograft patients with decompensated cirrhosis, regardless of treatment experience

Recommended regimens

  • Daily daclatasvir (60 mg) plus sofosbuvir (400 mg) with a low initial dose of ribavirin (600 mg; increase as tolerated) for 12 weeks
  • Daily fixed-dose combination of sofosbuvir (400 mg)/velpatasvir (100 mg) with weight-based ribavirin for 12 weeks

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