What are posttransplantation alternative treatment regimens for hepatitis C genotype 1, 4, 5, or 6, with or without compensated cirrhosis?

Updated: Oct 07, 2019
  • Author: Vinod K Dhawan, MD, FACP, FRCPC, FIDSA; Chief Editor: BS Anand, MD  more...
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Answer

◊ HCV genotype 1, 4, 5, or 6 allograft patients with or without compensated cirrhosis, regardless of treatment experience

Alternative regimens

  • Daily daclatasvir (60 mg) plus sofosbuvir (400 mg) with a low initial dose of ribavirin (600 mg; increase as tolerated) for 12 weeks
  • Genotype 1 or 4 infection only: Daily simeprevir (150 mg) plus sofosbuvir (400 mg) with or without weight-based ribavirin for 12 weeks
  • Daily fixed-dose combination of glecaprevir (300 mg)/pibrentasvir (120 mg) for 12 weeks

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