How is hepatitis C virus (HCV) infection managed in patients with HIV infection?

Updated: Oct 07, 2019
  • Author: Vinod K Dhawan, MD, FACP, FRCPC, FIDSA; Chief Editor: BS Anand, MD  more...
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Patients coinfected with human immunodeficiency virus (HIV) and hepatitis C virus (HCV) are at risk for accelerated liver fibrosis and should usually be offered antiviral treatment. [50] HIV/HCV-coinfected persons should be treated and retreated the same as those without HIV infection once any interactions with antiretroviral agents have been identified and managed. [9]  Daily daclatasvir plus sofosbuvir (400 mg), with or without ribavirin, is a recommended regimen when antiretroviral regimen changes cannot be made to accommodate alternative HCV direct-acting antiviral medications. However, the combination of ledipasvir/sofosbuvir for 8 weeks is not recommended, regardless of the patient's baseline HCV RNA level. [9]

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