What is the efficacy of combined NS5B targeting polymerase inhibitors for the treatment of hepatitis C (hep C) infection?

Updated: Oct 07, 2019
  • Author: Vinod K Dhawan, MD, FACP, FRCPC, FIDSA; Chief Editor: BS Anand, MD  more...
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Answer

The efficacy of combined simeprevir and sofosbuvir was investigated in the COSMOS study, an open-label, randomized phase II clinical trial. [110] For all patients (treatment-naïve and treatment-experienced, with or without cirrhosis), 93% achieved an SVR12 after 12 weeks of treatment, and 97% achieved SVR12 after 24 weeks of treatment. [110]

Dasabuvir is approved by the FDA only for use in combination with ombitasvir/paritaprevir/ritonavir. In the United States, this combination is marketed as Viekira Pak.


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