What are the adverse effects of interferon (IFN) for the treatment of hepatitis C (hep C) infection?

Updated: Oct 07, 2019
  • Author: Vinod K Dhawan, MD, FACP, FRCPC, FIDSA; Chief Editor: BS Anand, MD  more...
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Adverse effects are common with IFN and ribavirin combination therapy. Approximately 75% of patients experience one or more adverse effects.

Adverse effects of IFN include the following:

  • Hematologic complications (ie, neutropenia, thrombocytopenia)
  • Neuropsychiatric complications (ie, memory and concentration disturbances, visual disturbances, headaches, depression, irritability)
  • Flulike symptoms
  • Metabolic complications (ie, hypothyroidism, hyperthyroidism, low-grade fever)
  • Gastrointestinal complications (ie, nausea, vomiting, weight loss)
  • Dermatologic complications (ie, alopecia)
  • Pulmonary complications (ie, interstitial fibrosis)

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