What is the efficacy of combined interferon (IFN) and ribavirin for the treatment of hepatitis C (hep C) infection?

Updated: Oct 07, 2019
  • Author: Vinod K Dhawan, MD, FACP, FRCPC, FIDSA; Chief Editor: BS Anand, MD  more...
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A major advance in the treatment of chronic hepatitis C was the addition of the oral nucleoside analogue ribavirin to the interferon (IFN) regimen. As reported in the landmark 1998 studies by McHutchison et al [83] and Poynard et al, [84] IFN alfa-2b and ribavirin combination therapy for 6-12 months resulted in sustained eradication rates of 30%-40%. However, patients with HCV genotype 1 who were treated for 12 months had a much less favorable response than patients infected with genotypes 2 and 3 who received a 6-month course of therapy.

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