What are common serologic findings in patients with chronic hepatitis C (hep C) infection?

Updated: Oct 07, 2019
  • Author: Vinod K Dhawan, MD, FACP, FRCPC, FIDSA; Chief Editor: BS Anand, MD  more...
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Answer

Della Rossa et al reported that cryoglobulins are found in as many as 50% of persons with hepatitis C viral infection. [67] Hepatitis C virus (HCV) is the primary cause of essential mixed cryoglobulinemia (ie, type 2 cryoglobulinemia); as many as 90% of affected persons have HCV viremia. Cryoprecipitates usually contain large amounts of HCV antigens and antibodies. Vasculitis, arterial hypertension, purpura, lichen planus, arthralgias, and low thyroxine levels were associated with titers positive for cryoglobulin.

Other common serologic findings in patients with chronic HCV infection include one or more of the following [68] :

  • Antinuclear antibody (ANA)
  • Rheumatoid factor
  • Anticardiolipin antibody
  • Antithyroid antibody
  • Anti–smooth muscle antibody

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