What are the common extrahepatic manifestations of hepatitis C (hep C) infection?

Updated: Oct 07, 2019
  • Author: Vinod K Dhawan, MD, FACP, FRCPC, FIDSA; Chief Editor: BS Anand, MD  more...
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Symptoms often first develop as clinical findings of extrahepatic manifestations of HCV and most commonly involve the joints, muscle, and skin. In a large study of the extrahepatic manifestations of HCV, 74% of medical workers with HCV infection demonstrated extrahepatic manifestations, of which the following were the most common [46] :

  • Arthralgias (23%)
  • Paresthesias (17%)
  • Myalgias (15%)
  • Pruritus (15%)
  • Sicca syndrome (11%)

In addition, sensory neuropathy has been reported as an extrahepatic manifestation in 9% of patients with HCV infection. [47] Risk factors for manifestations of extrahepatic chronic hepatitis C infection include advanced age, female sex, and liver fibrosis.

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