What is the WHO recommendation for use of antiviral therapy to prevent vertical transmission of hepatitis B (HBV) (Hep B)?

Updated: Aug 01, 2018
  • Author: Nikolaos T Pyrsopoulos, MD, PhD, MBA, FACP, AGAF; Chief Editor: BS Anand, MD  more...
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HBV-monoinfected pregnant women should receive antiviral therapy as indicated for other adults, with tenofovir as the recommended NA. Currently, the WHO makes no recommendations for routine antiviral therapy for prevention of mother-to-child HBV transmission.

For HIV-infected pregnant and breastfeeding women (including those in the first trimester of pregnancy and women of childbearing age), the recommended first-line ART is a once-daily fixed-dose combination of tenofovir/lamivudine (or emtricitabine)/efavirenz (applicable to lifelong treatment as well as to ART initiated for prevention of mother-to-child HBV transmission and then stopped). (Strong recommendation)

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