What are the WHO guidelines for follow-up assessment of liver disease in hepatitis B (HBV) (Hep B)?

Updated: Jun 08, 2021
  • Author: Nikolaos T Pyrsopoulos, MD, PhD, MBA, FACP, AGAF; Chief Editor: BS Anand, MD  more...
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Conditional recommendation

In resource-limited settings, APRI (aspartate aminotransferase [AST]-to-platelet ratio index) is preferred to evaluate for liver fibrosis (APRI score >2 in adults).

Where resource availability and cost aren't major barriers, transient elastography (eg, FibroScan [measures tissue stiffness]) or FibroTest (5 biomarkers of liver fibrosis: gamma-2 macroglobulin, gamma-2 globulin, gamma globulin, apolipoprotein A1, gamma-glutamyl transpeptidase [GGT,] total bilirubin) may be preferred.

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