How long does hepatitis B (HBV) (Hep B) persist in the blood and what factors increase the risk of infection flare or reactivation?

Updated: Jun 08, 2021
  • Author: Nikolaos T Pyrsopoulos, MD, PhD, MBA, FACP, AGAF; Chief Editor: BS Anand, MD  more...
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Hepatitis B virus (HBV) may persist in the blood for decades after clinical recovery from acute hepatitis despite the presence of serum antibodies. Immunosuppressive conditions or drugs may allow dormant HBV to flare or reactivate. Additionally, genetic factors (eg, genetic mutations) may influence the risk for reactivation by affecting hepatitis B core antibody (anti-HBc) response. [107]

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