What is the efficacy of tenofovir for the treatment of HBeAg-positive hepatitis B (HBV) (Hep B)?

Updated: Aug 01, 2018
  • Author: Nikolaos T Pyrsopoulos, MD, PhD, MBA, FACP, AGAF; Chief Editor: BS Anand, MD  more...
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Answer

In a study that randomized patients to receive either tenofovir (300 mg once daily) or adefovir (10 mg once daily) for 48 weeks—with the adefovir-treated patients then switched to tenofovir—79% of the patients who received tenofovir were found to have a viral load below 400 copies/mL, whereas 76% of patients who received adefovir before switching to tenofovir were found to have a viral load below 400 copies/mL. [91]

In addition, 72% of patients in the adefovir arm who were found to have a viral load greater than 400 copies/mL achieved viral suppression after they were switched to tenofovir. For patients who achieved viral suppression on adefovir alone, the effect was maintained after they were switched to tenofovir. [91] Biochemical response was reported in 77% of patients in the tenofovir arm at week 72 and in 61% of those switching from adefovir to tenofovir.

With regard to seroconversion, 26% of patients who received tenofovir seroconverted at week 64, while in the adefovir arm, the observed seroconversion rate was reported as 21%. [91] It is noteworthy to mention that 5% of patients in the tenofovir arm experienced loss of the s antigen.


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